Vol 6 No 1 (2019)
Articles

Antidiabetic and Antihyperlipidemic Effects of Aqueous Extract of Carica papaya Leaf on the Experimental Model against Single Alloxan Toxicity

Ukpabi C.F.
Department of Biochemistry, Abia State Polytechnic, Aba, Nigeria
Chukwu M.N
Department of Biochemistry and Department of Food Technology Abia State Polytechnic, Aba, Nigeria
Onyemaechi, J.N.
Department of Chemistry, Abia State Polytechnic, Aba, Nigeria
Ibe P
Department of Chemistry, Abia State Polytechnic, Aba, Nigeria
Onuh E.F.
Department of Chemistry, Abia State Polytechnic, Aba, Nigeria
Published July 24, 2019
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Keywords
  • Carica papaya, Phytochemicals, Antidiabetic, hyperlipidemia activities, Lipoproteins, hyperglycermia
Citations
How to Cite
C.F., U., M.N, C., J.N., O., P, I., & E.F., O. (2019). Antidiabetic and Antihyperlipidemic Effects of Aqueous Extract of Carica papaya Leaf on the Experimental Model against Single Alloxan Toxicity. World Scientific Research, 6(1), 14-18. https://doi.org/10.20448/journal.510.2019.61.14.18

Abstract

Antidiabetic and antihyperlipidemic effects of aqueous extract of Carica papaya leaf on the toxicity were investigated. A total of thirty rats were divided into six groups of 5 rats: Group A: Normal control, Group B: Negative control, Group C: Positive control I, Group D: Positive control II, Group E: Test control I, Group F: Test control II. Diabetes was induced with a single dose of alloxan (120mg/kg) body weight and serum glucose was taken 72hrs after induction to confirm diabetes. The oral administration for hyperglycemia and hyperlipidemia started on the 4th and 8th day of the experiment respectively. The result showed that Carica papaya leaf extract significantly and progressively lowered the glucose level, TG, TC and LDL dose dependently while significantly causing a dose-related elevation in HDL concentration when compared to the untreated control and positive control groups (I & II) treated rats. Phytochemical analysis revealed the presence of alkaloids, flavonoids, saponins and tannins. The aqueous extract of this plant can be used to brew a tonic that will allay the metabolic disruption produced by diabetes.

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