Physiological and Hematological Changes induced by the Administration of Ciprofloxacin in Mice

Haleema Al Nahari

Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Saudi Arabia

Keywords: Mice, Ciprofloxacin, Hematological, White blood cell (WBC), Hematocrit (PCV%), aminotransferases, Uric acid and creatinine biochemical analysis.


The aim of the present work was to study the effect of Ciprofloxacin administration on hematological and biochemical alterations in blood mice. The results showed that red blood cell (RBC) count and hemoglobin concentration were significantly decreased in mice exposed to 0.5 and 1 mg/kg of Ciprofloxacin. Similar changes were observed with the mean corpuscular hemoglobin concentration (MCHC) and mean corpuscular hemoglobin (MCH). Meanwhile, White blood cell (WBC) count and the temporary hematocrit (PCV%) were significantly elevated in the two doses of Ciprofloxacin and remained elevated until the end of the experiment. The result showed also, that The administration of cadmium at 0.5 and 1 mg/kg/day in mice, caused a significant elevation in serum aminotransferases (AST and ALT) enzymatic activity in treated mice. There was a significant decrease in serum total protein in treated mice when compared with the control group. The liver glycogen recorded a significant decrease in treating mice and significant rises in serum uric acid and creatinine in treated mice compared with control. Ciprofloxacin treatment either at 0.5 and 1 mg/kg/day in mice causes biochemical disturbances in the major glycolytic–gluconeogenic pathways, hepatic marker enzymes.


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