Vol. 9 No. 1 (2022): In Progress
Articles

Role of Oxidative Stress as a Novel Therapeutic Target in Myocardial Injury Due to Ischemia/Reperfusion in Patients with Acute Myocardial Infarction

Pablo Morales-Carreno
Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile.
Ramon Rodrigo
Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile.

Published 2022-02-09

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Keywords

  • Oxidative stress, Antioxidants, Cardioprotection, Acute myocardial infarction, Vitamin C, Vitamin E, N-acetylcysteine, Polyphenols, Ischemia-reperfusion injury.

How to Cite

Morales-Carreno, P. ., & Rodrigo, R. . (2022). Role of Oxidative Stress as a Novel Therapeutic Target in Myocardial Injury Due to Ischemia/Reperfusion in Patients with Acute Myocardial Infarction. Journal of Life Sciences Research, 9(1), 1–13. https://doi.org/10.20448/lifsc.v9i1.3689

Abstract

The most effective therapeutic intervention for reducing infarct size and improving outcomes in patients with acute myocardial infarction is the thrombolytic therapy or percutaneous coronary angioplasty. However, this process itself can generate ischemia-reperfusion injury that can be responsible for up to 50% of the final infarct size. Considering oxidative stress as the main damaging agent in this pathology, it has been postulated that reinforcing antioxidant defenses could improve cardiac function. However, up to date clinical trials based on monotherapies have been consistent in the favorable results. In this review the pathophysiological mechanisms of myocardial injury due to ischemia/reperfusion in patients undergoing percutaneous coronary angioplasty are updated. In addition, new therapeutic alternatives for cardioprotection in this population, are explored, with emphasis in the combined therapy as a novel antioxidant treatment for this myocardial injury.

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