Neurophysiological Effect of Pentoxifyllin on Male Albino Rats
Somaya M.Ismail
Cairo University–Faculty of Science, Department of Zoology
Hayat A. Ismail
Biology department,faculty of science,KingAbd El Aziz University,Saudi Arabia
Keywords: Pentoxifyllin, Neurotransmitters, Male albino rats, Acetylcholinesterase, Asparaginet, GABA, Glycine, Serine glutamate, Aspartate level.
Abstract
The objective of the present work is to study the possibility of involved neurotransmitters in the CNS side effects due to the administration of Pentoxifyllin in male albino rats. The frontal cortex of Pentoxifyllin treated groups revealed decrease of glutamate, GABA and elevation of aspartate, asparagines, glycin, serine levels and AChE activities in a time related effect. In the hippocampus area there are elevation of asparaginet, GABA, glycine, serine level but reductions of glutamate, aspartate level and AChE activities in a time related effect. Overall, the data suggest that there is a shift in the balance between neurotranamitters towards increased production of excitatory potency in groups subjected to Pentoxifyllin administration.